Thermo Fisher Scientific Adiponectin Receptor 1 Polyclonal Antibody
Adiponectin Receptor 1을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 ELISA에 적합하며, 세포막 단백질 검출에 유용합니다. 액상 형태로 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–59 of human Adiponectin Receptor 1 (NP_0570832) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.08 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805963 |
Product Specific Information
- Positive Samples: BT-474, Mouse skeletal muscle
- Cellular Location: Cell membrane, Multi-pass membrane protein
- Immunogen sequence:
MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQE
Target Information
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes.
This insulin-sensitizing effect of adiponectin is mediated by increased fatty-acid oxidation through activation of AMP kinase and PPAR-γ. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Both receptors contain seven transmembrane domains and mediate adiponectin-induced AMP kinase and PPAR-γ activities, fatty-acid oxidation, and glucose uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-90213_Adiponectin_Receptor_1_Q96A54-1_Rabbit.svg, PA5-90213_Adiponectin_Receptor_1_Q96A54-1_Rabbit_PDP.jpeg)
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