Thermo Fisher Scientific HD Monoclonal Antibody (3F9)

Applications and Tested Dilution

Product Specifications

Immunogen

HD (NP_002102, 81 a.a. approximately 190 a.a) partial recombinant protein with GST tag.
Molecular weight of GST tag alone: 26 kDa.

Target Family: Huntingtin
UniProt ID: P42858-1
Species: Human (NCBI Node ID: 9606)
Antigen Range: 81–190

Product Specific Information

Protein Sequence:
AVAEEPLHRP KKELSATKKD RVNHCLTICE NIVAQSVRNS PEFQKLLGIA MELFLLCSDD AESDVRMVAD ECLNKVIKAL MDSNLPRLQL ELYKEIKKNG APRSLRAALW

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.
HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.

The huntingtin locus spans 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development. Two alternatively polyadenylated forms are expressed with different abundance in fetal and adult tissues.
The larger transcript (~13.7 kb) is mainly in brain tissue, while the smaller (~10.3 kb) is expressed more broadly. The genetic defect may not eliminate transcription but may alter mRNA or protein function.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.