Thermo Fisher Scientific OPA1 Polyclonal Antibody
OPA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC에 사용 가능. 인간, 생쥐, 돼지 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 미토콘드리아 형태 유지 연구에 적합.
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Thermo Fisher Scientific OPA1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 5 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Pig, Rat, Zebrafish |
| Published Species | Mouse, Pig |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 500–600 of human OPA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2158151 |
Product Specific Information
- This antibody shares 100% sequence homology with primate and 94% with zebrafish.
- Suggested positive control: human brain protein.
Target Information
OPA1 is a dynamin-related GTPase critical for maintaining mitochondrial morphology and mtDNA integrity. Mutations in OPA1 are commonly associated with heterozygous optic atrophy, a dominant trait that causes reduced visual clarity and potential blindness. The disease typically begins in childhood and worsens over time due to degeneration of optic nerve fibers.
OPA1 dysfunction has also been linked to certain schizophrenia-related nerve degeneration and mitochondrial network abnormalities. The protein plays a key role in apoptosis regulation and cellular metabolism.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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