Thermo Fisher Scientific COL11A2 Polyclonal Antibody
Rabbit polyclonal antibody against human COL11A2, validated for WB and ELISA. Recognizes amino acids 210–380 of COL11A2. Supplied as a liquid, affinity purified, 0.49 mg/mL in PBS with 50% glycerol. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 210–380 of human COL11A2 (NP_5424112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.49 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901148 |
Product Specific Information
Positive Samples: A375, HepG2, K-562
Immunogen Sequence:
IVPGVQAAYE SCEQKELECE GGQRERPQNQ QPHRAQRSPQ QQPSRLHRPQ NQEPQSQPTE SLYYDYEPPY YDVMTTGTTP DYQDPTPGEE EEILESSLLP PLEEEQTDLQ VPPTADRFQA EEYGEGGTDP PEGPYDYTYG YGDDYREETE LGPALSAETA HSGAAAHGPR G
Target Information
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6, close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer, with the third alpha chain being a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that forms an amino terminal domain.
Mutations in this gene are associated with:
- Type III Stickler syndrome
- Otospondylomegaepiphyseal dysplasia (OSMED syndrome)
- Weissenbacher-Zweymuller syndrome
- Autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)
- Autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53)
Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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