Thermo Fisher Scientific ENO1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive Samples: PC-3, Ramos, NCI-H460, HeLa, THP-1, Mouse kidney, Mouse liver

Immunogen Sequence:
MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV VIGMDVAASE FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV TESLQACKLA QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK

Target Information

Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It consists of three subunits: alpha, beta, and gamma.
Non-neuronal enolase (ENO1) is an isoform composed of two alpha subunits. The ENO1 gene also encodes a shorter monomeric structural lens protein, tau-crystallin.

ENO1 functions in glycolysis and is involved in processes such as growth control, hypoxia tolerance, and allergic responses. It may act as a receptor and activator of plasminogen on cell surfaces of leukocytes and neurons, stimulating immunoglobulin production.

ENO1 is used as a diagnostic marker for various tumors and hypoxic brain injury, and as a marker for endometriosis. Antibodies against alpha-enolase are associated with cancer-associated retinopathy syndrome (CAR) and identified as autoantigens in Hashimoto encephalopathy (HE), linked to Hashimoto thyroiditis (HT).

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.