Thermo Fisher Scientific PCBP1 Polyclonal Antibody
Thermo Fisher Scientific의 PCBP1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 Western blot, IHC, ICC/IF, ELISA에 적합합니다. 합성 펩타이드 면역원 기반의 rabbit IgG 항체로, 액상 형태이며 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human hnRNP E1/PCBP1 (NP_0061872) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.01 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901145 |
Product Specific Information
- Positive Samples: NIH/3T3, HepG2, MCF7, Mouse liver, Rat liver
- Immunogen sequence:
LRLVVPATQC GSLIGKGGCK IKEIRESTGA QVQVAGDMLP NSTERAITIA GVPQSVTECV KQICLVMLET LSQSPQGRVM TIPYQPMPAS SPVICAGGQD R
Target Information
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. PCBP1 and PCBP2 have paralogues that arose from duplication events of entire genes. The encoded protein appears multifunctional and, along with PCBP2 and hnRNPK, forms major cellular polydomains involved in RNA binding.
PCBP1 functions as a translational coactivator of poliovirus RNA via sequence-specific interaction with stem-loop IV of the IRES and promotes RNA replication by binding to its 5′-terminal cloverleaf structure. It is also implicated in translational control of 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. Additionally, it may contribute to formation of a sequence-specific alpha-globin mRNP complex associated with alpha-globin mRNA stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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