Thermo Fisher Scientific Neuron specific beta-Tubulin III Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-1 µg/mL

-

Miscellaneous PubMed (Misc)

-

View 3 publications 3 publications

Product Specifications

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH-coupled synthetic peptide from C-terminal of human neuron specific beta-Tubulin III (Swiss Prot: Q13509) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Beta III Tubulin,uniProtId:Q13509-1,ncbiNodeId:9606,antigenRange:450,antigenLength:450,antigenImageFileName:A01627-40_Beta_III_Tubulin_Q13509-1_Rabbit.svg,antigenImageFileNamePDP:A01627-40_Beta_III_Tubulin_Q13509-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/ml.

Neuron specific β-Tubulin III, also known as tubulin beta-4, belongs to the tubulin family. It is the major constituent of microtubules and forms dimers of alpha and beta chains. One mole of tubulin binds to two moles of GTP, one binding is an exchangeable site of the beta chain and the other is at a non exchangeable site of the alpha chain. Neuron specific β-Tubulin III is regarded as a neuron-specific marker. The expression of neuron specific β-Tubulin III has been implicated in signal neuronal commitment in primitive neuroepithelium. In addition, increased expression of neuron specific β-Tubulin III occurs during cancer formation which leads to the development of anti-tubulin drugs.GenScript Neuron Specific β-Tubulin III Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human neuron specific β-Tubulin III (Swiss Prot: Q13509). This antibody label neuronal cell bodies, dendrites, axons, and axonal terminations and is used identify newly committed neurons. In addition, it serves an excellent loading control when normalizing data specifically for neuronal expression.

Target Information

The betaIII-tubulin isoform is present dominantly in cells of neuronal origin and it is one of the earliest markers of neuronal differentiation. It is regarded as a specific probe for the cells of neuronal origin as well as for the tumours originating from these cells. The betaIII-tubulin is most abundant in cells of neuronal origin, but was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.