Thermo Fisher Scientific TNFR1 Polyclonal Antibody
Mouse TNFR1 인식하는 Rabbit Polyclonal Antibody로 ELISA, WB, Flow Cytometry, IP, Functional Assay에 적합. Extracellular region을 면역원으로 사용하며 Protein A로 정제됨. 0.1 mg/mL 농도, PBS + 0.1% BSA buffer, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50 | View publication |
| Flow Cytometry (Flow) | 1:50 | - |
| ELISA | 1:50 | - |
| Immunoprecipitation (IP) | 1:50 | - |
| Functional Assay | 1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Extracellular region of murine TNF-R I |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087960 |
Product Specific Information
PA1-40282 detects TNF-R I from mouse samples.
It has been successfully used in ELISA, functional assays, flow cytometry, immunoprecipitation, and Western blot applications.
The immunogen is the extracellular region of mouse TNF-R I.
Endotoxin level: <24 EU/mg.
Target Information
TNFR1 (Tumor necrosis factor receptor 1) is a member of the tumor necrosis factor superfamily and functions as a major TNF-alpha receptor.
It plays key roles in cytokine-mediated signaling, positive regulation of NF-κB pathway, angiogenesis, and negative regulation of gene expression.
The extracellular domain is released into circulation as soluble TNFR1 (sTNFR1).
In humans, the TNFR1 gene is located on chromosome 12.
TNFR1 interacts with BAG4/SODD, TRADD, and TRAF2, which regulate receptor-mediated signal transduction.
Germline mutations in the extracellular domain are associated with autosomal dominant periodic fever syndrome due to impaired receptor clearance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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