Thermo Fisher Scientific COL11A2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Control: Human COL11A2-transfected 293T cells (partial fragment)
• Predicted Reactivity: Mouse (89%), Rat (89%), Bovine (93%)
• Note: Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain.

Mutations in this gene are associated with:

• Type III Stickler syndrome
• Otospondylomegaepiphyseal dysplasia (OSMED syndrome)
• Weissenbacher-Zweymuller syndrome
• Autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13)
• Autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53)

Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.