Thermo Fisher Scientific CSK Polyclonal Antibody
CSK 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB 및 IHC(P) 적용 가능. 인간에 반응하며, 다양한 종에서 예측 반응성 있음. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human CSK (exact sequence proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 0.1M glycine, 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2735690 |
Product Specific Information
- Positive Control: 293T, A431, H1299, Molt-4, Raji
- Predicted Reactivity: Mouse (98%), Rat (98%), Zebrafish (89%), Pig (97%), Chicken (94%), Rhesus Monkey (100%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CSK is a tyrosine kinase that downregulates SRC oncoprotein activity through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by mechanisms interfering with this phosphorylation, the CSK gene may function as an antioncogene.
CSK plays a key role in regulating cell growth, differentiation, migration, and immune responses. It phosphorylates tyrosine residues in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1.
CSK is ubiquitously expressed as a cytosolic protein (~50 kDa), with a fraction localized to lipid rafts via interaction with PAG (Csk-binding protein).
안전 및 규제 정보
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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