Thermo Fisher Scientific NOD3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human NOD3. Recombinant protein control fragment (Product #RP-104842). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOD3,uniProtId:Q7RTR2-1,ncbiNodeId:9606,antigenRange:58-146,antigenLength:1065,antigenImageFileName:PA5-65491_NOD3_Q7RTR2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-65491_NOD3_Q7RTR2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663829

Product Specific Information

Immunogen sequence: SNDSRIQRHRK ALLSKVGGGP ELGGPWHRLA SLLLVEGLTD LQLREHDFTQ VEATRGGGHP ARTVALDRLF LPLSRVSVPP RVSITIGV

Highest antigen sequence identity to the following orthologs - mouse 79%, rat 74%.

Target Information

NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-βB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.