Thermo Fisher Scientific EGLN1/EGLN2 Polyclonal Antibody
인간 EGLN1/EGLN2 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot 및 ELISA에 적합합니다. 합성 펩타이드(aa 250-350)를 면역원으로 사용하며, 액상 형태로 제공됩니다. 고순도 친화 크로마토그래피 정제, 안정적 저장(-20°C) 가능.
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Thermo Fisher Scientific EGLN1/EGLN2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acids 250–350 of human EGLN1/EGLN2 (NP_0713341 / NP_4442741) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS (pH 7.3) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855088 |
Product Specific Information
Immunogen sequence:
DIRGDKITWI EGKEPGCETI GLLMSSMDDL IRHCNGKLGS YKINGRTKAM VACYPGNGTG YVRHVDNPNG DGRCVTCIYY LNKDWDAKVS GGILRIFPEG K
Target Information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates specific prolines in the oxygen-dependent degradation (ODD) domains of HIF1A and HIF2A, targeting them for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, hydroxylation is attenuated, allowing HIFs to escape degradation, translocate to the nucleus, and activate hypoxia-inducible genes. EGLN1 plays a key role in normoxic regulation of HIF1 stability and angiogenesis-related processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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