Thermo Fisher Scientific FGFR3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human FGFR3, validated for WB, IHC(P), and ICC/IF. Lyophilized form, reconstitutable to 500 µg/mL. Suitable for research on FGFR signaling, bone development, and related diseases. For research use only.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific FGFR3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a sequence at the N-terminus of human FGFR3 (110–129aa RQRLTQRVLCHFSVRVTDAP) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746378 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
FGFR3 is a member of the FGFR family of receptor tyrosine kinases, which regulate cellular processes such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair. FGFR family members differ in ligand affinities and tissue distribution.
A full-length FGFR3 protein includes:
- Three extracellular immunoglobulin-like domains
- A single hydrophobic membrane-spanning segment
- A cytoplasmic tyrosine kinase domain
The extracellular portion interacts with fibroblast growth factors, triggering downstream signaling that influences mitogenesis and differentiation. FGFR3 plays a role in bone development and maintenance. Mutations are associated with craniosynostosis and skeletal dysplasia. Three alternatively spliced transcript variants encoding different isoforms have been described.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.