Thermo Fisher Scientific FGFR3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

FGFR3 is a member of the FGFR family of receptor tyrosine kinases, which regulate cellular processes such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair. FGFR family members differ in ligand affinities and tissue distribution.
A full-length FGFR3 protein includes:

• Three extracellular immunoglobulin-like domains
• A single hydrophobic membrane-spanning segment
• A cytoplasmic tyrosine kinase domain

The extracellular portion interacts with fibroblast growth factors, triggering downstream signaling that influences mitogenesis and differentiation. FGFR3 plays a role in bone development and maintenance. Mutations are associated with craniosynostosis and skeletal dysplasia. Three alternatively spliced transcript variants encoding different isoforms have been described.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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