Thermo Fisher Scientific OCTN1/SLC22A4 Polyclonal Antibody

Thermo Fisher Scientific OCTN1/SLC22A4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Carnitine (β-hydroxy-γ-trimethylaminobutyrate) is a small, highly polar compound that aids in β-oxidation of long-chain fatty acids.
Organic cation/carnitine transporters (OCTN) assist in elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney.
OCTN proteins localize to the plasma membrane of epithelial cells.

• OCTN1: Expressed in kidney, trachea, bone marrow, and fetal liver
• OCTN2: Expressed in kidney, skeletal muscle, placenta, and heart
• OCTN3: Expressed strongly in testis and weakly in kidney

The human OCTN1 gene maps to chromosome 5 and OCTN2 to chromosome 5q31.
Mutations in OCTN2 cause systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia, and hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.

제품 이미지

(이미지 파일명: ACT-014-200UL_SLC22A4_Q9Z306-1_Rabbit.svg, ACT-014-200UL_SLC22A4_Q9Z306-1_Rabbit_PDP.jpeg)