Thermo Fisher Scientific Phospho-MECP2 (Ser80) Polyclonal Antibody
Human MECP2 단백질의 Ser80 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Dot blot 검증 완료. Protein A 및 항원 친화 크로마토그래피로 정제되어 높은 특이성과 순도를 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-MECP2 (Ser80) Polyclonal Antibody
Applications
- Dot blot (DB)
Tested Dilution: 1:500
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S80 of human MeCP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2144007 |
Product Specific Information
This antibody is predicted to react with mouse, non-human primate, and rat based on sequence homology.
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that have a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, a key modification in eukaryotic genomes essential for mammalian development. It represses transcription from methylated gene promoters and differs from other MBD family members by being X-linked and subject to X inactivation. MECP2 is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological developmental disorder common in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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