Thermo Fisher Scientific Phospho-Claudin 2 (Tyr224) Polyclonal Antibody
인간 Claudin 2 단백질의 Tyr224 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, 세포 간 접합부 연구에 적합. Dot blot에서 검증되었으며, Protein A 및 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Applications
- Dot blot (DB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y224 of human CLDN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2082539 |
Target Information
Tight junctions are specialized regions of cell-cell contact that are particularly abundant in luminal epithelial cell sheets. In electron micrographs, tight junctions appear as belt-like bands of sealing strands that encircle each cell, functioning as a molecular gasket to prevent ion and molecule leakage. Beyond this barrier role, tight junctions maintain epithelial polarity by blocking diffusion of membrane proteins between apical and basolateral surfaces.
Proteins associated with tight junctions include ZO-1, ZO-2, ZO-3, cingulin, Rab-3b, and symplekin. Claudin-1 and Claudin-2 are key structural components of tight junction strands, inducing networks of strands characteristic of true tight junctions. Claudin-2 also functions as a paracellular channel with cation (Na⁺) selectivity and is primarily expressed in liver and kidney tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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