Thermo Fisher Scientific TIS11D Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 200-250 of human TIS11D if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TIS11D,uniProtId:P47974-1,ncbiNodeId:9606,antigenRange:200-250,antigenLength:494,antigenImageFileName:PA5-36248_TIS11D_P47974-1_Rabbit.svg,antigenImageFileNamePDP:PA5-36248_TIS11D_P47974-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2553439

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 40 kDa.

Purity is >95% by SDS-PAGE.

Target Information

TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5UUAUUUAUUU-3 core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.