Thermo Fisher Scientific HFE2 Polyclonal Antibody
Human HFE2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 유세포분석(Flow Cytometry)에 적합. KLH 결합 합성 펩타이드(308-338 aa)로 면역화됨. 철 대사 연구 및 hepcidin 관련 신호 경로 분석에 활용 가능. 단백질 A 및 항원 친화 크로마토그래피로 정제됨.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Flow Cytometry (Flow)
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 308–338 amino acids from the C-terminal region of human HFE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544203 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in this gene cause hemochromatosis type 2A (juvenile hemochromatosis), an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically occurring before age 30.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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