Thermo Fisher Scientific PMS2/PMS2CL Polyclonal Antibody
Rabbit polyclonal antibody against human PMS2/PMS2CL, validated for WB, IHC, and ICC/IF. Detects endogenous PMS2/PMS2CL involved in DNA mismatch repair. Suitable for research use only; stored at -20°C in PBS with glycerol.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PMS2CL (Accession Q68D20), corresponding to amino acid residues D124–C174 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854378 |
Product Specific Information
Antibody detects endogenous levels of total PMS2/PMS2CL.
Target Information
Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially binds to mismatched DNA, followed by binding of MutH endonuclease and MutL to form a complex that excises the mismatch.
In humans, hMSH2 encodes a MutS homologue, and hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are linked to hereditary nonpolyposis colon cancer (HNPCC), a common hereditary disease characterized by microsatellite instability due to replication errors.
Both hPMS1 and hPMS2 are mutated in the germline of HNPCC patients. The PMS2 and MLH1 complex (MutLa) from HeLa cells can complement MLH1 deficiency in hypermutable colorectal tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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