Thermo Fisher Scientific MOV10L1 Polyclonal Antibody
MOV10L1 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며, PBS와 50% 글리세롤 용액에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MOV10L1 (Accession Q9BXT6), corresponding to amino acid residues Q317–L367 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854379 |
Product Specific Information
Antibody detects endogenous levels of total MOV10L1.
Target Information
MOV10L1 Isoform 1:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, mediating repression of transposable elements during meiosis by forming complexes with piRNAs and Piwi proteins, and governing methylation and subsequent repression of transposons. Specifically binds to piRNA precursors and promotes generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Displays 5′–3′ RNA unwinding activity, facilitating piRNA precursor processing.
MOV10L1 Isoform 2:
May act downstream of MEF2C during heart formation, functioning as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, potentially through regulation of CDKN1A (additional evidence required).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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