Thermo Fisher Scientific ASIC1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:200
• Immunohistochemistry (IHC): Assay-dependent

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• Ships as a lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels with intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop containing many cysteine residues with conserved spacing.

The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. It acts as a cation channel with high affinity for sodium, gated by extracellular protons, and inhibited by amiloride. ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺, and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, cortical regions, hippocampus, amygdala, cerebellum, and other brain regions. Isoform 3 is expressed only in dorsal root ganglion, while isoform 1 is expressed in DRG, spinal cord, and trigeminal ganglia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.