Thermo Fisher Scientific NaV1.8 (SCN10A) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For long-term storage, aliquot and store at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit.
It mediates voltage-dependent sodium ion permeability of excitable membranes and plays a role in neuropathic pain mechanisms.
Members of the Deg/ENaC superfamily share structural similarity, possessing two intracellular termini, two membrane-spanning segments, and a large extracellular loop with conserved cysteine-rich regions.
ENaC isoforms (α, β, γ) regulate sodium and fluid balance in kidney, lung, and colon, and are involved in aldosterone-dependent sodium reabsorption and blood pressure regulation.
Mutations in ENaC subunits are associated with Liddle’s syndrome and pseudohypoaldosteronism (PHA-1).
Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2 and Sodium Channelopathy-Related Small Fiber Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.