Thermo Fisher Scientific Phospho-MYH9 (Tyr158) Polyclonal Antibody
Phospho-MYH9 (Tyr158) 폴리클로날 항체로, 인간 MYH9 단백질의 인산화 부위를 인식. Rabbit IgG 기반으로 Dot blot에 적합하며, 단백질 A 및 항원 친화 크로마토그래피로 정제됨. PBS buffer(0.09% sodium azide) 용액 형태로 제공되며, 4°C 단기 또는 -20°C 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Dot blot (DB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y158 of human MYH9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718226 |
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is part of a hexameric complex, which includes two heavy chains, two regulatory light chains, and two essential light chains.
The NMHC IIA protein interacts with actin filaments and is involved in cellular activities such as:
- Cell migration
- Adhesion
- Division
- Maintenance of cell shape
Mutations in MYH9 can cause autosomal dominant disorders known as MYH9-related diseases (MYH9-RD), including:
- May-Hegglin anomaly
- Fechtner syndrome
- Epstein syndrome
These disorders are characterized by macrothrombocytopenia (abnormally large platelets) and may lead to hearing loss, renal failure, and cataracts.
MYH9 is also essential in hematopoiesis, ensuring survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function can disrupt hematopoiesis, resulting in severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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