Thermo Fisher Scientific B7-H4 Monoclonal Antibody (Clone 9), PE, eBioscience
마우스 B7-H4 단백질을 인식하는 PE 결합 단일클론 항체로, Flow Cytometry 분석에 최적화되어 있습니다. Clone 9은 비차단형 항체이며, T세포 활성 조절 연구 및 암 면역학 연구에 활용됩니다. 4°C 보관, 동결 금지.
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Thermo Fisher Scientific B7-H4 Monoclonal Antibody (Clone 9), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested dilution: 0.5 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1 |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Clone 9 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466069 |
Product Specific Information
The Clone 9 monoclonal antibody reacts with mouse B7S1, also known as B7H4 — a newly discovered member of the B7 family. B7S1 is thought to regulate T-cell costimulation influenced by B-cell activation status. The ligand for B7S1 has not been identified, and this antibody is non-blocking.
Double staining with anti-mouse B7-H4 antibodies Clone 9 and 188 suggests that their epitopes differ or do not interfere sterically when used together.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Tested on transfected cells; ≤0.5 µg per test (100 µL final volume). Cell number may vary between 10⁵–10⁸ cells/test. Antibody titration recommended for optimal performance.
Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
B7-H4 (B7x, VTCN1) is a costimulatory protein functioning as a negative regulator of T-cell mediated immunity. Although its receptor is unknown, B7-H4 delivers inhibitory signals to T-cells, suppressing proliferation, cell cycle progression, and IL-2 production.
B7-H4 deficient mice show minimal immune alteration, suggesting its role in fine-tuning T-cell responses. It is expressed on activated T-cells, B-cells, monocytes, and dendritic cells. Abnormal expression is linked to lung, breast, and ovarian cancers.
B7-H4 primarily localizes on lymphoid cell membranes and interacts with T lymphocyte receptors to modulate immune responses. Overexpression may help tumor cells evade immune detection and facilitate progression.
VTCN1 may serve as a biomarker for early detection of ovarian cancer and renal cell carcinoma (RCC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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