Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), PE, eBioscience

Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 0.25 µg/test
Publications: View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• Request custom conjugation

Product Specific Information

The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is expressed on T cells, B cells, monocytes, neutrophils, and dendritic cells. It acts as a receptor for herpes simplex virus (HSV) entry through interaction with viral glycoprotein D (gD). The cytoplasmic region of HVEM binds TRAF family members, mediating signal transduction that activates immune responses. HVEM also interacts with BTLA, regulating lymphocyte activation and homeostasis.

Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Pre-titrated and validated for flow cytometry with normal human peripheral blood cells. Recommended usage: 0.25 µg/test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green.
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

TNFRSF14, a TNF-receptor superfamily member, functions as a mediator of HSV entry via binding to viral glycoprotein D. Its cytoplasmic domain interacts with TRAF proteins, activating immune signaling pathways. TNFRSF14 activation in T cells induces proliferation and cytokine production, contributing to inflammation and CTL-mediated tumor immunity. This protein is a potential target for modulating immune responses. Multiple splice variants exist, though some full-length forms remain uncharacterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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