Thermo Fisher Scientific Phospho-DNA-PK (Thr2647) Polyclonal Antibody
인간 DNA-PK Thr2647 인산화 부위를 인식하는 폴리클로날 항체로, IHC 및 ICC/IF에 적합합니다. Rabbit IgG 포맷으로 제공되며, 액상 상태(1 mg/mL)로 -20°C 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA538475
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-DNA-PK (Thr2647) Polyclonal Antibody
Applications and Tested Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human DNA-PK around the phosphorylation site of threonine 2647 (T-L-TP-Q-T) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555075 |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules targeting PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator required for expression of most genes. This complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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