Thermo Fisher Scientific Phospho-DNA-PK (Thr2638) Polyclonal Antibody
인간 DNA-PK의 Thr2638 인산화 부위를 인식하는 폴리클로날 항체입니다. ICC/IF에 사용 가능하며, 농도는 1 mg/mL 액상 형태입니다. 연구용으로 DNA 손상 반응 및 신호전달 연구에 적합합니다. -20°C에서 보관합니다.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human DNA-PK around the phosphorylation site of Thr2638 (R-A-TP-Q-Q) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555077 |
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been found for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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