Thermo Fisher Scientific Phospho-Dematin (Ser403) Polyclonal Antibody
인산화된 Dematin(Ser403)을 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 실험에 적합. 액상 형태로 제공되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Dematin around the phosphorylation site of Ser403 (K-A-SP-L-F) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555072 |
Target Information
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner.
This protein contains a core domain in the N-terminus and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, it exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide.
The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located.
Disruption of this gene has been correlated with autosomal dominant Marie Unna hereditary hypotrichosis, while loss of heterozygosity is thought to play a role in prostate cancer progression.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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