Thermo Fisher Scientific Phospho-Dematin (Ser403) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100

Product Specifications

Target Information

The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner.
This protein contains a core domain in the N-terminus and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, it exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide.
The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located.
Disruption of this gene has been correlated with autosomal dominant Marie Unna hereditary hypotrichosis, while loss of heterozygosity is thought to play a role in prostate cancer progression.
Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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