Thermo Fisher Scientific Phospho-MCM4 (Ser54) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated MCM4 (Ser54). Validated for Western blot. Supplied as liquid, unconjugated form at 1 mg/mL. Suitable for studying DNA replication and cell cycle regulation. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human MCM4 around the phosphorylation site of Ser54 (P-T-SP-P-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555074 |
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC) and may participate in replication fork formation and recruitment of DNA replication-related proteins. The MCM complex (MCM2, 4, 6, 7) possesses DNA helicase activity and functions as a DNA unwinding enzyme. Phosphorylation of MCM4 by CDC2 kinase reduces helicase activity and chromatin binding. This gene is located on chromosome 8, adjacent to PRKDC/DNA-PK, a kinase involved in DNA double-strand break repair. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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