Thermo Fisher Scientific IL-23 p19 Polyclonal Antibody
Human IL-23 p19 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 중화 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 보존제가 없는 동결건조 형태. 높은 특이성과 낮은 교차 반응성을 제공.
- 카탈로그번호
- PA546913
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Neutralization (Neu) | 0.2–0.8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human IL-23 p19 (Arg20–Pro189) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577112 |
Product Specific Information
- In direct ELISA, approximately 50% cross-reactivity with recombinant canine IL-23p19.
- Less than 25% cross-reactivity with recombinant feline IL-23p19.
- Less than 5% cross-reactivity with recombinant mouse IL-23p19, recombinant human IL-12p40, and recombinant rat IL-23p40.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level <0.10 EU per 1 µg of antibody (LAL method).
Target Information
IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. The p19 subunit, similar to p35 of IL-12, is biologically inactive alone. IL-23 interacts with IL-12Rβ1 and the IL-23R receptor, containing a STAT4 binding domain. It is secreted by activated mouse and human dendritic cells.
Mouse IL-23 differs from IL-12 in biological activity: it does not induce significant IFN-γ production but strongly promotes memory T cell proliferation and IL-17 production.
Human IL-23 also induces memory T cell proliferation and moderate IFN-γ production compared to IL-12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-46913_IL-23_p19_Q9NPF7-1_Goat.svg)
(이미지: PA5-46913_IL-23_p19_Q9NPF7-1_Goat_PDP.jpeg)
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