Thermo Fisher Scientific IL-23 p19 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISA, approximately 50% cross-reactivity with recombinant canine IL-23p19.
• Less than 25% cross-reactivity with recombinant feline IL-23p19.
• Less than 5% cross-reactivity with recombinant mouse IL-23p19, recombinant human IL-12p40, and recombinant rat IL-23p40.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level <0.10 EU per 1 µg of antibody (LAL method).

Target Information

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. The p19 subunit, similar to p35 of IL-12, is biologically inactive alone. IL-23 interacts with IL-12Rβ1 and the IL-23R receptor, containing a STAT4 binding domain. It is secreted by activated mouse and human dendritic cells.
Mouse IL-23 differs from IL-12 in biological activity: it does not induce significant IFN-γ production but strongly promotes memory T cell proliferation and IL-17 production.
Human IL-23 also induces memory T cell proliferation and moderate IFN-γ production compared to IL-12.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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