Thermo Fisher Scientific TIM-1 Polyclonal Antibody
Human TIM-1 단백질을 인식하는 Goat Polyclonal Antibody로, WB, IHC, ELISA에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose로 보존됩니다. 인간 시료에 반응하며, 교차 반응성이 매우 낮습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–15 µg/mL |
| ELISA | 0.1–0.4 µg/mL (Detection), 0.2–0.8 µg/mL (Capture) |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human TIM-1/KIM-1/HAVCR Ser21–Thr288 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606144 |
Product Specific Information
- In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse TIM-1, recombinant rat TIM-1, and recombinant human TIM-4 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Binding occurs via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity.
CD365 participates in T-cell co-stimulation and is primarily expressed in epithelial cells, as well as in A549, 769-P, and Caco-2 cell lines.
A soluble form is generated by metalloproteinase-mediated proteolytic cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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