Thermo Fisher Scientific TIM-1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse TIM-1, recombinant rat TIM-1, and recombinant human TIM-4 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein with an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses.
Binding occurs via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity.
CD365 participates in T-cell co-stimulation and is primarily expressed in epithelial cells, as well as in A549, 769-P, and Caco-2 cell lines.
A soluble form is generated by metalloproteinase-mediated proteolytic cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.