Thermo Fisher Scientific EXD1 Monoclonal Antibody (OTI1A2), TrueMAB
Thermo Fisher Scientific EXD1 단일클론 항체(OTI1A2)는 인간 EXD1 단백질을 인식하는 Mouse IgG1 형 항체입니다. Western blot, ICC/IF, Flow cytometry에 사용 가능하며, 고순도 친화 크로마토그래피 정제 및 안정적 PBS/BSA/glycerol buffer로 제공됩니다.
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Thermo Fisher Scientific EXD1 Monoclonal Antibody (OTI1A2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Flow Cytometry (Flow) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A2 |
| Immunogen | Full-length human recombinant protein of human EXD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.77 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis.
The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins.
It governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for germline integrity.
The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.
In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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