Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI3D4), TrueMAB
MAPK7 단백질을 인식하는 Mouse monoclonal antibody. Western blot, ICC/IF, Flow Cytometry에 사용 가능. Human 시료에 반응하며, 고순도 affinity chromatography로 정제됨. PBS/BSA/glycerol buffer에 보관되며 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D4 |
| Immunogen | Full length human recombinant protein of human MAPK7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and participates in diverse cellular processes such as proliferation, differentiation, transcription regulation, and development.
MAPK7 is activated by MAP2K5/MEK5 and mediates downstream signaling of various receptors. Upon extracellular stimulation, MAPK7 translocates to the nucleus to regulate gene expression via phosphorylation of transcription factors.
Gene deletion in mice causes defective vascular and cardiac development, indicating its essential role in endothelial function and vascular integrity.
ERK5 is expressed in multiple adult tissues including heart, placenta, lung, kidney, and skeletal muscle, but is not detectable in liver.
Four alternatively spliced transcript variants encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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