Thermo Fisher Scientific CD243 (ABCB1) Monoclonal Antibody (UIC2)
CD243 (ABCB1) 단백질을 인식하는 UIC2 클론의 mouse monoclonal antibody. 인간 시료 반응성으로 IHC, Flow Cytometry, IP, Functional Assay 등에 사용 가능. 1 mg/mL 농도의 액상 형태로, preservative-free PBS buffer에 보관. 4°C에서 보관, 동결 금지.
- 카탈로그번호
- MA528587
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD243 (ABCB1) Monoclonal Antibody (UIC2)
Thermo Fisher Scientific CD243 (ABCB1) Monoclonal Antibody (UIC2)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Flow Cytometry (Flow) | 1–4 µg/mL |
| Immunoprecipitation (IP) | Assay-Dependent |
| Functional Assay (Functional) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UIC2 |
| Immunogen | Human CD243 (MDR-1) cDNA-transfected NIH 3T3 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745546 |
Product Specific Information
This antibody recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, and on many multidrug-resistant cancer cells.
It preferentially recognizes CD243 during substrate transport.
Low endotoxin, azide-free phosphate-buffered saline (PBS) solution, 0.2 µm filter sterilized.
Endotoxin level is less than 0.01 EU/µg of protein (LAL test).
Recommended Application Notes:
- Immunohistochemistry (Paraffin): Heat-mediated antigen retrieval in citrate buffer (pH 6)
- Functional Application: Inhibition
Target Information
The membrane-associated protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily.
ABC proteins transport various molecules across cellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White.
CD243 (P-glycoprotein) is a member of the MDR/TAP subfamily and functions as an ATP-dependent drug efflux pump with broad substrate specificity.
It contributes to multidrug resistance by decreasing drug accumulation in cells and mediates resistance to anticancer drugs.
Additionally, it acts as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
제품 이미지
(이미지 없음 또는 제거됨)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.