Thermo Fisher Scientific CD87 (UPAR) Monoclonal Antibody (VIM5), PE
CD87(uPAR)을 인식하는 PE 결합 단일클론 항체로, 인간 시료에 적합합니다. Flow cytometry 및 IHC(Frozen/PFA) 응용에 사용 가능하며, 세포 표면 단백질 발현 분석에 유용합니다. 4°C에서 암소 보관하며 동결 금지.
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Applications
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: Not specified
- Publications: View 1 publication
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Not specified
- Publications: View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VIM5 |
| Immunogen | Human myeloid cell line THP-1 (target: uPAR (CD87), UniProt ID: Q03405-1, range: 1–335 aa) |
| Conjugate | PE (R-phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745547 |
Product Specific Information
This antibody recognizes CD87 (urokinase plasminogen activator receptor), a 36–68 kDa single-chain GPI-anchored extracellular glycoprotein expressed on granulocytes, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts, and keratinocytes.
Recommended dilution is for 100 µL of whole blood or 1×10⁶ cells in suspension.
Target Information
The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in both normal and pathological processes.
The human PLAUR cDNA encodes 335 amino acids including a 22-residue signal peptide and a hydrophobic C-terminal region, producing a highly glycosylated 50 kDa protein anchored to the plasma membrane via a GPI linkage.
PLAUR (uPAR) associates with the carbohydrate-binding domain of SELL on neutrophil membranes, analogous to its interaction with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas, showing a 33-fold increase in advanced stages compared with normal tissue. Protein expression correlates with recurrence and mortality rates, suggesting UPAR as a prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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