Thermo Fisher Scientific GFAP Monoclonal Antibody (OTI2D8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

GFAP (Glial fibrillary acidic protein) is a class III intermediate filament protein predominantly expressed in astrocytes and certain astroglia of the central nervous system. It is also found in satellite cells of peripheral ganglia and non-myelinating Schwann cells. Neural stem cells strongly express GFAP, making it a useful marker for astrocytic cells.
GFAP expression is elevated in various brain tumors derived from astrocytic cells and is also present in lens epithelium, Kupffer cells, salivary tumors, and erythrocytes. It serves as a marker to distinguish astrocytes from other glial cells during development.
Mutations in the GFAP gene cause Alexander disease, a rare astrocytic disorder of the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.