Thermo Fisher Scientific ZFP36 Monoclonal Antibody (OTI3C3), TrueMAB
인간 ZFP36 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, ICC/IF, Flow cytometry에 적합. Lyophilized 형태로 제공되며 PBS buffer에 trehalose 포함. 성장인자 반응 조절 연구 및 macrophage 유전자 발현 조절 관련 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C3 |
| Immunogen | Full length human recombinant protein of human ZFP36 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ZFP36 is a probable regulatory protein with a zinc finger structure involved in growth factor response regulation.
Knockdown of ZFP36 increases macrophage gene mRNAs and inflammatory tumor necrosis factor protein release, while overexpression decreases these levels, indicating its role in macrophage gene expression regulation.
ZFP36 can be phosphorylated by JNK and other MAP kinase family members.
Gene expression profiling suggests its involvement in prostate cancer prognosis, and abnormal ZFP36 production may contribute to higher rheumatoid arthritis activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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