Thermo Fisher Scientific IL-10 Monoclonal Antibody (CC318)
소, IL-10을 인식하는 Mouse Monoclonal Antibody (Clone CC318). Flow Cytometry 및 ELISA에 사용 가능. IL-10의 생물학적 활성 억제 없이 면역조절 연구에 적합. Protein A 정제, PBS buffer, 4℃ 또는 -20℃ 보관.
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Thermo Fisher Scientific IL-10 Monoclonal Antibody (CC318)
Applications
- Flow Cytometry (Flow): Assay-dependent
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC318 |
| Immunogen | Plasmid cDNA encoding bovine IL-10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745423 |
Product Specific Information
Mouse anti-Bovine Interleukin-10 antibody, clone CC318 recognizes bovine IL-10.
This antibody has been shown not to inhibit the biological activity of IL-10.
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and some lymphocytes.
It plays a key role in immunoregulation and inflammation by:
- Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
- Enhancing B cell survival, proliferation, and antibody production
- Blocking NF-kappa B activity
- Regulating the JAK-STAT signaling pathway
Knockout studies in mice indicate IL-10 is essential for intestinal immune regulation.
Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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