Thermo Fisher Scientific IL-12/IL-23 p40 Monoclonal Antibody (CC326)
소, IL-12/IL-23 p40 서브유닛을 인식하는 단클론 항체. Flow cytometry, ELISA, 기능적 분석에 사용 가능. 단백질 A로 정제된 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
| Functional Assay | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CC326 |
| Immunogen | Recombinant bovine IL-12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745424 |
Product Specific Information
Mouse anti-Bovine Interleukin-12/23 antibody, clone CC326 recognizes the p40 subunit of bovine interleukin-12.
Target Information
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages, and human lymphoblastoid cells in response to antigenic stimulation.
IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40).
IL-23 is a heterodimeric cytokine that shares the IL-12B subunit with IL-12 and includes an IL-23A (IL-23p19) subunit.
Functionally, IL-12 increases expression of vascular endothelial adhesion molecule-1 on endothelium, directs leukocytes toward tumors, and facilitates ischemic-hemorrhagic necrosis of tumor tissue.
IL-23 plays an important role in stimulating memory T-cells and is required for induction, expansion, maintenance, and downstream effector functions of Th17 cells, which are vital for upregulating neutrophil chemokines and pro-inflammatory cytokines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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