Thermo Fisher Scientific DLAT Recombinant Rabbit Monoclonal Antibody (JE34-38)
DLAT 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot과 IHC(P)에서 검증됨. 인간, 마우스, 랫트 반응성. 단백질 A 정제, 1 mg/mL 농도, 액상 형태. 미토콘드리아 매트릭스 내 DLAT 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE34-38 |
| Immunogen | Synthetic peptide within human Pyruvate Dehydrogenase E2 aa 574–624/647 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3094244 |
Product Specific Information
- Positive control: Human testis tissue, mouse cerebellum tissue, rat brain tissue, SK-Br-3 cell lysate, K562 cell lysate, Daudi cell lysate, HL-60 cell lysate
- Predicted band size: 69 kDa
- Subcellular Location: Mitochondrion matrix
Target Information
DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A.
Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed, leading to cirrhosis and liver failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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