Thermo Fisher Scientific PSME2 Recombinant Rabbit Monoclonal Antibody (PSH0-10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Positive Control: PC-12 cell lysate, 293T cell lysate, mouse liver tissue lysate, rat thymus tissue lysate, MCF-7 cell lysate, PC-3 cell lysate, HeLa, rat stomach tissue, human rectal carcinoma tissue, HepG2
• Predicted Band Size: 27 kDa
• Subcellular Location: Cytosol, Extracellular region or secreted, Nucleus

Target Information

Proteolytic degradation is crucial for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channel regulation, cell cycle, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most proteins in the cytosol and nucleus, while others are processed via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit molecular complex (~2.5 MDa) composed of a 20S core and 19S regulatory subunits that recognize ubiquitinated proteins and facilitate their degradation.
Defects in this pathway are associated with diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.