Thermo Fisher Scientific CD38 Recombinant Rabbit Monoclonal Antibody (PD01-49)
CD38 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등에 적합합니다. 인간 시료 반응성이 있으며, Protein A로 정제된 고순도 항체입니다. CD38 관련 질환 연구 및 세포 활성화 표지에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50 |
| Flow Cytometry (Flow) | 1 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD01-49 |
| Immunogen | Synthetic peptide within human CD38 aa 250–300/300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092905 |
Product Specific Information
- Positive control: Daudi cell lysates, human tonsil tissue, A549
- Predicted band size: 34 kDa
- Subcellular Location: Membrane
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase or as a cell surface receptor.
Antibodies to CD38 are useful in:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., myeloma identification)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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