Thermo Fisher Scientific MRP2 Recombinant Rabbit Monoclonal Antibody (JA32-01)
MRP2 단백질을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 민감도를 제공. WB, IHC, ICC, Flow 등 다양한 응용에 적합. HEK293 세포 발현 시스템 기반으로 생산되어 로트 간 일관성이 우수. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:800 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | 1 publication |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA32-01 |
| Immunogen | Synthetic peptide within Human MRP2 (aa 1496–1545) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809964 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
This gene encodes a membrane-associated guanylate kinase (MAGUK) family protein. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions.
The encoded protein is an extensively palmitoylated membrane phosphoprotein containing PDZ, SH3, and guanylate kinase domains. It interacts with cytoskeletal and junctional proteins across various tissues and may regulate:
- Cell shape and polarity
- Hair cell development
- Neural patterning of the retina
- Tumor suppression pathways
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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