Thermo Fisher Scientific Caveolin 1 Monoclonal Antibody (7C8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA1-40241 detects Caveolin-1 from rat samples.
It recognizes caveolin-1 alpha as well as caveolin-1 beta, which are present in many tissues such as aorta, heart, muscle, lung, adipose white, brown, and epididymal fat.
MA1-40241 can be used to immuno-isolate caveolae.
It has been successfully used in immunofluorescence, immunoprecipitation, and Western blot applications.
The immunogen is rat caveolin.

Positive control: Adipocytes (3T3-L1 adipocytes)
Negative control: Cytoplasmic extracts of adipocytes

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and regulates their activity. Caveolin-1 is involved in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated T-cell activation.
It can bind with DPP4 and induce T-cell proliferation and NF-kappa-B activation in a TCR/CD3-dependent manner.
Mutations in the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.