Thermo Fisher Scientific Caveolin 1 Monoclonal Antibody (7C8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

-

Immunocytochemistry (ICC/IF)

1:50

-

Immunoprecipitation (IP)

1:50

-

Product Specifications

Species Reactivity

Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

7C8

Immunogen

Rat caveolin-1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2292467

Product Specific Information

MA1-40241 detects Caveolin-1 from rat samples.

MA1-40241 recognizes caveolin-1 alpha as well as caveolin-1 beta, which are present in many tissues, like aorta, heart, muscle, lung, adipose white, brown and epidydimal fat. MA1-40241 can be used to immuno-isolate caveolae.

MA1-40241 has been successfully used in immunofluorescence, immunoprecipitation and Western blot applications.

The MA1-40241 immunogen is rat caveolin.

Positive control: Adipocytes (3T3-L1 adipocytes); Negative control: Cytoplasmic extracts of adipocytes.

Target Information

Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.