Thermo Fisher Scientific ASGR1 Monoclonal Antibody (8D7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:50

-

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

1:50

-

Immunocytochemistry (ICC/IF)

-

View 2 publications 2 publications

Flow Cytometry (Flow)

1:50

View 1 publication 1 publication

ELISA (ELISA)

1:50

-

Product Specifications

Species Reactivity

Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

8D7

Immunogen

Crude rat liver membrane extracts if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ASGR1,uniProtId:P02706-1,ncbiNodeId:10114,antigenRange:1-284,antigenLength:284,antigenImageFileName:MA1-40244_ASGR1_P02706-1_House_mouse.svg,antigenImageFileNamePDP:MA1-40244_ASGR1_P02706-1_House_mouse_PDP.jpeg,sortOrder:3}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

View additional formats

• FITC
• Request custom conjugation

Form

Liquid

Concentration

0.1 mg/mL

Purification

Protein G

Storage buffer

PBS with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2059674

Product Specific Information

MA1-40244 detects ASGPR from rat and human samples.

MA1-40244 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunofluorescence, and Western blot applications. The typical starting working dilution is 1:10.

The MA1-40244 immunogen is crude rat liver membrane extracts.

Positive control: Rat hepatocytes; Negative control: Rat kidney, pancreas, small intestine, colon.

Target Information

The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalization and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i. e. it is present on the sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed. The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.