Thermo Fisher Scientific LDLR Monoclonal Antibody (OTI7C5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The low density lipoprotein receptor (LDL-R) family includes cell surface proteins responsible for receptor-mediated endocytosis of specific ligands. LDL binds at the cell membrane and is internalized into lysosomes, where it is degraded to release cholesterol. This process regulates HMG CoA reductase activity, a key enzyme in cholesterol synthesis, and stimulates cholesterol ester formation.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R also acts as an entry factor for Hepatitis C virus, along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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