Thermo Fisher Scientific LDLR Monoclonal Antibody (OTI4E9), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The low density lipoprotein receptor (LDL-R) gene family comprises cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds at the cell membrane and is internalized into lysosomes, where the protein is degraded and cholesterol becomes available for regulation of HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Mutations in the LDL-R gene cause familial hypercholesterolemia. LDL-R also acts as an entry factor for Hepatitis C virus, along with SCARB1, CLDN1, and CD81. At least three isoforms of LDL-R are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.