Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal Antibody로, WB 및 IP에 적합합니다. 인간 IRAK1의 575–625 영역을 면역원으로 사용하며, 액상 형태로 1 mg/mL 농도입니다. 4°C에서 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- A303743Ax (2개 옵션)
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
- Publications: [References not provided]
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 and 625 of human Interleukin-1 Receptor-Associated Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Its association with MYD88 leads to phosphorylation by IRAK4, followed by autophosphorylation and kinase activation. IRAK1 can also phosphorylate TIRAP to promote ubiquitination and degradation, and phosphorylate IRF7 to induce activation and nuclear translocation, leading to transcriptional activation of type I IFN genes that drive antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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