Thermo Fisher Scientific IRAK1 Polyclonal Antibody
IRAK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot과 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제됨. 인간 시료에 반응하며 액상 형태로 제공되고 4°C에서 보관 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 and 625 of human Interleukin-1 Receptor-Associated Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways.
IRAK1 is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation.
Its association with MYD88 leads to IRAK1 phosphorylation by IRAK4, followed by autophosphorylation and kinase activation.
IRAK1 can also phosphorylate TIRAP to promote its ubiquitination and degradation, and phosphorylate IRF7 to induce its activation and nuclear translocation, resulting in transcriptional activation of type I IFN genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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