Thermo Fisher Scientific Beta-Arrestin 1 Polyclonal Antibody
Beta-Arrestin 1 단백질을 검출하기 위한 Thermo Fisher Scientific의 토끼 폴리클로날 항체. WB, IHC, IP 등 다양한 응용에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. 4°C 보관, 습식 얼음 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 368 and 418 of human Arrestin, Beta 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Beta Arrestin 1 is a member of a protein family widely expressed, particularly abundant in the central nervous system. Acting as an adaptor or scaffold molecule, Beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G-protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.
Upon ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and ERK2 on serine 412 in a negative feedback mechanism and binds to phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated, leading to GPCR internalization and activation of the Ras–Raf–ERK1/2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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