Thermo Fisher Scientific Beta-Arrestin 1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

Beta Arrestin 1 is a member of a protein family widely expressed, particularly abundant in the central nervous system. Acting as an adaptor or scaffold molecule, Beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G-protein-coupled receptors (GPCRs), such as the beta 2-adrenergic receptor.
Upon ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and ERK2 on serine 412 in a negative feedback mechanism and binds to phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated, leading to GPCR internalization and activation of the Ras–Raf–ERK1/2 signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.